Colonic Drug Absorption- Part 1: Colon Physiology and its Environment for Drug Absorption

Tuesday, April 4, 2023, 12:30-2pm ET

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Extent of colonic absorption of a drug is function of colon physiology and drug’s physico-chemical properties. For any given drug, its small intestinal absorption will be different than its colonic absorption due to the physiological and physiochemical differences between these two parts of the intestine. The first webinar of this series will focus on understanding colon physiology and its impact on drugs absorption.

Speaker: Clive Wilson, Ph.D., Strathclyde University

New USP Dissolution Performance Verification Standard: What, Where, and When

Thursday, April 6, 2023,12:30-2 pm ET

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The USP announced the release of a new PVT calibration standard called the Dissolution Performance Verification Standard – Prednisone. The new calibrator is expected to come into effect 01-May-2023 at which point the old Prednisone Reference material stops being valid. Mark Liddell, Manager, Dosage Form Performance Laboratory at the USP will present the new calibrator and will answer questions regarding its implementation.

Speaker: Mark Liddell, Ph.D., USP

Measuring the Opalescence of mAb Solutions with Microscale Nephelometry

Tuesday, April 11, 2023, 12:30-2pm ET

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The visual opacity of protein solutions, known as opalescence, is a phenomenon arising from molecular self-association that is quantified via turbidimetry. Commercially available turbidimeters generally require mL-scale quantities of sample. Using low volumes (< 10 µL), the 90o static light scattering channel of a microcuvette-based dynamic/static light scattering instrument was found to provide stable measurements of opalescence across a broad dynamic range, spanning nephelometric turbidity unit (NTU) values relevant for mAb solutions. These microscale nephelometric measurements are in good agreement with those made using a commercial turbidimeter, but with the low sample consumption necessary for screening paradigms.


Jon Kingsbury, Ph.D., Wyatt

Xujun Zhang, Ph.D., Wyatt

Retractions Are On The Rise, But Not Enough

Tuesday, April 18, 2023, 12:30-2pm ET

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In 2000, there were about 40 retractions from the scientific literature. In 2022, there were nearly 5,000. That is a dramatic increase, even accounting for the growing number of papers published per year. In this talk, I will explore the reasons for the increase, why it is good news, and why the real number should be even higher. I will tell the stories of the sleuths who are finding problems in the literature, drawing on more than a decade of experience at Retraction Watch.

Speaker:  Ivan Oransky, MD, Retraction Watch

Colonic Drug Absorption- Part 2: Developing Colon-targeting Formulations

Thursday, April 20, 2023, 12:30-2 pm ET

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There are two major reasons for developing colon-targeting formulations. The first is to create extended-release formulations for rapidly absorbed immediate-release products in order to limit number of daily doses to one or two. Such products typically rely on their good colonic absorption. The second is the targeted release of drugs in colon for the treatment of colonic diseases, in which case the absorption from the colon might not be desired. This webinar will be focus on formulation design and strategies in pursuit of colonic release.


Filippos Kesisoglou, Ph.D., Merck & Co.

Joseph Della Rocca, Ph.D., Merck

Colonic Drug Absorption- Part 3: Predicting Colonic Absorption

Thursday, April 27, 2023, 12:30-2 pm ET

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Prediction of colonic absorption is of high interest to guide development of extended-release formulations or just evaluating drug’s potential for colonic absorption to avoid the unnecessary experiments, in case when a drug absorbs poorly from the colon. Physiologically based absorption models are widely used for this purpose. Despite being imperfect, these models allow to save time and costs associated with in vivo studies. In this webinar, the most recent advancements in modeling of colonic absorption will be discussed.

Speaker: Konstantinos Stamatopoulos, Ph.D., Certara

Career Transition in Industry: Why, When and How?

Tuesday, May 23, 2023, 12:30-2:00 pm ET

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Career transitions are huge milestones for anyone and there can be countless factors to take into account when considering one. Often times we run into situations where we might be thinking of switching jobs but are not sure if we are making the right decisions. In this webinar, the PPDM community would like to invite two seasoned scientists from industry who have had some very successful career transitions and also have experienced different company sizes and setup. We would like to learn from their experience and seek advice in a panel discussion on topics related to career transitions within industry. 


Yang Chen, Ph.D., Daiichi Sankyo

Amitava Mitra, Ph.D., FAAPS, Kura Oncology

Past Webinars

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