Systems pharmacology is the science of advancing knowledge about drug action at the molecular, cellular, tissue, organ, organism, and population levels. There are two particular aspects central to this field. One is at the level of molecular mechanisms of cellular pharmacodynamics wherein understanding drug effect requires a consideration of multipathway networks of signaling, metabolism, and gene expression. Second is at the level of models describing organ physiology and organism-level physiology. Systems pharmacology leverages advancements in mathematical and computational fields in advancing vertical integration, i.e., bottom-up models of detailed molecular mechanisms at the cellular level to converge with top-down models describing organ physiology and organism-level physiology.
Advantages of Systems Pharmacology
The advantages of systems pharmacology within clinical pharmacology and translational research are immense. An example is leveraging clinical information as it relates to integrating clinical datasets and biological samples with systems biology, which can facilitate the definition of subpopulations through molecular profiling, support target ID, assist in the selection of biomarkers for patient selection and drug response, and rapidly exploit improvements in biomarker technology for platform development. Another advantage is in understanding druggable pathways to discover new targets based on systems biology. Third, leveraging marketing and sales with systems pharmacology can improve drug development decision making via rational selection of new drug candidates. Modern systems pharmacology has stemmed from the complex interplay in translating and predicting disease pathophysiology and drug effects in patients using methods and concepts of systems pharmacology to advance molecular medicine.
This focus group will advance state-of-the-art knowledge and programming about topics at the interface of systems biology within AAPS. Specifically, the focus group will debate the scientific issues inherent in this field, foster an enhanced integration of research efforts with educating and training via collaborative programming, brainstorm likely barriers to advancing the field, and most notably work to enhance collaboration between pharmacologists, clinicians, and systems biologists.
- Advance the science and applications of systems pharmacology in drug discovery and development and pharmacotherapy.
- Promote and strengthen collaboration with multidisciplinary scientists and physicians.
- Provide a platform and forum for educating quantitative systems biologists and pharmacologists by developing learning opportunities.
- Provide opportunities for knowledge exchange and networking between its members and members of AAPS and other related professional societies.
- Serve as a resource for AAPS members on the application of various technologies/strategies used in the advancement of systems pharmacology.
Section affiliations: BIOTEC | CPTR | PPDM