Immunogenicity of Biopharmaceuticals

Edited by:
Marco van de Weert, The Danish University of Pharmaceutical Sciences, Denmark
Eva Horn Møller, The Danish University of Pharmaceutical Sciences, Denmark

Volume 8 of the AAPS Press series, Biotechnology: Pharmaceutical Aspects.

A particular issue for biopharmaceuticals that has not been addressed comprehensively in any book is the potential of an immune response to the biopharmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be relatively harmless, but may also cross-react with the endogenous compound, causing autoimmunogenicity. Recent adverse experiences in Europe with Janssen-Ortho's blockbuster product Eprex have increased the attention towards potential immunogenicity of biopharmaceuticals, above all from the regulatory agencies.

This book is intended to give a broad overview of the current state-of-the-art regarding the immune response to biopharmaceuticals. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.

Written for: Researchers, professionals, and students in the areas of pharmaceutical science, pharmacology, pharmaceutical biotechnology, immunology/virology, (autoimmunity, vaccines), and genetics

List Price: $189.00; AAPS Member price: $141.75      

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