This technology is very commonly used to enhance solubility and stability of conventional
and biomolecules. There are several applications of these and continue to grow.
Currently there is no forum where it is discussed and updated. It will benefit scientists
or academicians who are working on proteins or conventional small molecules and
looking various methods to store, solubilize and create dry dosage forms as lyophilized
for sub-cutaneous/IV or spray freeze dried microspheres or powder for pulmonary
delivery or solid dosage form for oral delivery. It will benefit anyone who involves
drying at any stage of product development. Selection of right processing method
is critical for successful development of a drug product. There are several different
ways to remove water, but the method of choice depends on the formulation, route
of delivery as well as the stability of the API. Most commonly used drying methods
are – freeze-drying, spray drying, spray-freeze drying, foam drying, supercritical
fluid drying and cryopreservation. Each of these techniques has its own advantages
and disadvantages. All of these techniques are currently used throughout pharmaceutical
and biotech industry to manufacture drug products and their application continues
to grow. There is plethora of challenges associated with these drying technologies
in terms of formulation, process development and ultimately scale up. Unfortunately,
there is no forum where information on these drying techniques is discussed and
updated. This focus group will benefit scientists, from both industry and academia,
who are working on proteins or conventional small molecules and looking at various
methods to improve stability, increase solubility and create dry dosage forms. This
can be a freeze-dried product for sub-cutaneous/IV delivery or spray freeze dried
microspheres or controlled particle size powder for pulmonary delivery or solid
dosage form for oral delivery.
2008-2009 Goals and Objectives
- Establish a core group of interested scientists throughout industry and academia
to explore diverse areas of drying technologies (Freeze-drying, Spray drying, Vacuum
drying, Foam drying, Spray Freeze Drying, Super Critical Fluid Drying, Cryopreservation);
- Provide a forum to discuss scientific and technical issues related to drying technologies
and also exchange experiences, ideas and information;
- Define technical issues related to drying technologies (process vs. formulation
vs. scale-up);
- Organize quality programs for the AAPS Annual Meeting and to conduct workshops,
symposia and round tables on current trends in drying pharmaceutical/biotech drug
products.
JOIN THE Freezing and Drying Technologies FOCUS GROUP
To join the Freezing and Drying Technologies Focus Group, click here.
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