The Microdialysis focus group aims to be a stimulant and vehicle for the exchange of information and discussions on the microdialysis technique with respect to its important current applications and future potentials in quantitative drug research and development.
Within the last decades, it has become clear that in vivo microdialysis is of unique value in quantitative pharmacological research. It is the only in vivo technique that is able to provide temporal information on local free concentrations of drugs and metabolites in the extracellular space at specific sites in the body. Thus, quantitative in vivo microdialysis studies have provided new information on drug delivery to, for example, the central nervous system and subcutaneous sites,; on distribution to the liver, lung, muscle, adipose, and other target tissues; and on the characterization of blood levels of drug and metabolites. The microdialysis technique is closely connected to the research fields of drug delivery, drug metabolism, pharmacokinetics, and pharmacodynamics, while the state-of-art analytical technologies are needed and expansion of microdialysis applications will follow progress in analytical technologies.
Membership is open to any AAPS member who has an interest in microdialysis. The chair and steering committee hope to serve the Microdialysis focus group members by organizing podium and poster presentations, symposia, and other mechanisms for adequate exchange of information. We are open to suggestions from the members.
Section affiliations: PPDM | APQ | CPTR