Thursday, March 22, 2012
12:30 pm–1:30 pm
Organized by the Preformulation focus group
Conducted by Eric J. Munson, Ph.D., College of Pharmacy, University of Kentucky
Moderated by Harry Brittain, Ph.D., Center for Pharmaceutical Physics
About the Webinar
The ability to effectively deliver solid pharmaceuticals is directly related to the form of the drug in the solid state. Drugs may be formulated in several different states, including amorphous, crystalline, or diluted with excipients. In addition, many drugs exhibit polymorphism, or the ability to exist in two or more crystalline phases that differ in the arrangement or conformation of the molecules in the crystal lattice. We are developing solid-state NMR spectroscopy as a technique for the analysis of pharmaceuticals. We are particularly interested in characterizing the effects of formulation on the properties of pharmaceutical solids.
In this webinar new developments and applications of solid-state NMR spectroscopy to study pharmaceuticals will be presented. A new probe design that facilitates high-throughput solid-state NMR will be shown. The ability to quantify the amounts of multiple crystalline and amorphous forms present in formulations will be described. The effects of differences in relaxation parameters and cross polarization efficiencies on characterizing mixtures of forms will be addressed. The ability to study common pharmaceutical excipients will be presented. Finally, correlations of formulation parameters with line widths and relaxation times will be presented.
Information provided by SSNMR
- Quantitation—API and formulations
- Comparison of analytical techniques
- Predicting drug stability—crystalline and amorphous
- Excipient characterization
About the Presenter
Eric J. Munson, Ph.D., is the Patrick DeLuca Professor in Pharmaceutical Technology at the University of Kentucky College of Pharmacy. He has held the position of professor in the Department of Pharmaceutical Chemistry at the University of Kansas since 2006 and was an associate professor in that department starting 2001. Prior to that, he was a faculty member at the University of Minnesota (1994 to 2001). Munson received his bachelor's degree from Augustana College in Sioux Falls, S.D. After studying one year in Munich, Germany on a Fulbright Fellowship, he continued his education at Texas A&M University, where he received his doctorate in 1993. He then spent one year as a postdoctoral fellow at the University of California, Berkeley.
His research program is focused on the characterization of pharmaceutical solids using a variety of analytical techniques, with an emphasis on solid-state NMR spectroscopy. He is a recipient of an NSF CAREER award and was named a Fellow of the American Association of Pharmaceutical Scientists in 2009.