AAPS Good Oral CandidatesSubscribe


GOC101Selecting Candidates with Optimal Oral Exposure eLearning Series 

"Common oral exposure issues include low exposure in certain species, high variability in exposure, loss of exposure over time, and less or greater than dose-proportional exposure. Each issue can have multiple root causes and it is important to establish the root cause early in drug discovery. This AAPS eCourse consists of eleven lectures that will discuss the fundamental causes behind oral exposure issues, the tools that can be used to investigate them and the mitigation strategies that can be adopted to address them."—Sachin Lohani, Ph.D

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The ability to achieve the requisite systemic exposures is critical to the success of preclinical safety studies, as well as to the viability of new drug candidates in the clinic. When an exposure issue is encountered, it is essential to understand the contribution of physicochemical and pharmacokinetic properties to the problem so that the correct strategy can be used to enhance exposure. This course will focus on challenges encountered with the oral delivery of drug candidates.This course will step through the fundamentals of achieving optimal oral exposure. After attending all lectures the participants will have a high level understanding of:

• Oral absorption and the impact of phase and formulation design
• GI physiology
• Drug metabolism and transporters
• In vitro and in vivo screening tools
• PBPK-based approaches to model oral absorption

See a full listing of AAPS Good Oral Candidates101's lecture titles, instructors, reviewers, and CORE team members.


Single Lecture Pricing
Purchase Type  Per Lecture Price 
Introductory Price $119.00
AAPS Member $99.00
Student/Academic $51.00


Full Course Pricing

Purchase the entire course at an even greater discount! This includes all eleven lectures. 

Purchase Type  Full Course Price 
Introductory Price $879.00
AAPS Member $709.00
Student/Academic $399.00


Bulk Pricing

Bulk pricing is available. For bulk pricing information, contact elearning@aaps.org.